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A phase III, double-blind, randomized placebo-controlled study to evaluate the effects of dalcetrapib on cardiovascular(CV) risk in a genetically defined population with a recent Acute Coronary Syndrome (ACS): The DAL-302 (dal-GenE-2) trial.

The recently completed dal-GenE study, a clinical trial of over 6,000 patients, evaluated the effects of dalcetrapib in patients with recent ACS and the AA genetic variant. The results of this large study demonstrated that treatment with dalcetrapib did not change the risk of having another cardiovascular event in the majority of patients with recent ACS. However, an analysis was performed which indicated that the COVID-19 pandemic may have impacted the accuracy of this data. When the results collected before the start of the COVID-19 pandemic were evaluated, certain analyses showed that taking dalcetrapib corresponded to a reduction in chance of experiencing a myocardial infarction (heart attack) when compared to those taking placebo (dummy drug). The goal of the present study is to evaluate the effect of dalcetrapib only in patients with the AA genetic variant to confirm these findings of cardiovascular benefit. 

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