Tirzepatide versus Placebo in Patients with Nonalcoholic Steatohepatitis (NASH)
Eligibility
Inclusion Criteria
– 18 to 80 years old
– must have a BMI ≥27 and ≤50 kg/m²
– if diabetic A1c <9.5%
- diagnosis of NASH with stage 2 or 3 fibrosis by liver biopsy
- have had heart attack, stroke, or hospitalization for congestive heart failure in the past 6 months
Exclusion Criteria
– uncontrolled high blood pressure
– eGFR <30
- diagnosis of type 1 diabetes
- history of pancreatitis
- Liver disease due alcohol, hepatitis B or C, or any other form of liver disease
- active cancer within the last 5 years