Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure (ASTRAAS)

In by ECIR

Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure (ASTRAAS)

  • Hidden
  • This field is for validation purposes and should be left unchanged.
clinicaltrials.gov

Eligibility

Inclusion Criteria
  1. Male or Female 18 to 80 years of age
  2. SBP 140 to 170 mmHg
  3. Stable on ≥ 3 antihypertensive agents
  4. BMI ≤ 45 kg/m2
Exclusion Criteria
  1. Diagnosis of T1DM
  2. A1c > 9%
  3. Secondary HTN
  4. SBP ≥  180 mmHg or DBP ≥  110 mmHg
  5. HF NYHA Class III & IV
  6. History of MI, coronary revascularization, stroke, or TIA within 1 year
  7. GFR < 45 ml/min or UACR > 300 mg/g
Back to Current Studies