Effect of Aprocitentan in the Treatment of Difficult to Control High Blood Pressure (PRECISION)
Eligibility
Inclusion Criteria
≥ 18 years of age
uncontrolled BP despite at least 3 background anti-hypertensive medications
Treated with at least 3 anti-hypertensive drugs from different classes (must include a diuretic)
SBP ≥ 140 mmHg
Exclusion Criteria
High BP due to white coat effect, medical inertia, poor therapeutic adherence, or secondary causes of hypertension
SBP ≥180 mmHg and/or DBP ≥110 mmHg
Severe renal insufficiency