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The purpose of this study is to evaluate the effectiveness of 2 doses or 3 doses of GSK’s licenced meningococcal group B Bexsero (rMenB+OMV NZ) vaccine and of 2 doses of GSK’s investigational combined meningococcal (MenABCWY) vaccine (GSK3536819A) in healthy adolescents and young adults.

Location(s): Lake CIty

Condition: Vaccine

The purpose of this study is to determine if an AF detection intervention using a two week heart monitor in men and women at least 70 years of age with undiagnosed atrial fibrillation (AF) or atrial flutter (AFL) reduces the person-years incidence rate of stroke compared to usual care (no AF detection intervention).

Location(s): Jacksonville (Headquarters), Jacksonville- LaVilla (Downtown), Lake CIty

Condition: Heart Disease

This study compares insulin icodec (a new insulin taken once a week) to insulin glargine (an insulin taken once daily which is already available on the market) in people with type 2 diabetes.

Location(s): Jacksonville (Headquarters)

Condition: Diabetes

This is a phase 2 study is evaluating drug LY3209590 safety and effectiveness compared to insulin degludec in subjects with type 1 diabetes.

Location(s): Jacksonville- LaVilla (Downtown), Macon

Condition: Diabetes

This is a randomized, double-blind, placebo-controlled, dose-ranging Phase 2 study to evaluate the efficacy and safety of drug CIN-107 compared to placebo in patients with treatment-resistant hypertension (rHTN). The study will assess three oral doses of CIN-107 versus placebo.

Location(s): Jacksonville (Headquarters)

Condition: Resistant Hypertension

This study is evaluating the InterStim Micro system performance and safety to confirm long term outcomes

Location(s): Jacksonville (Headquarters)

Condition: Fecal Incontinence, Non-obstructive Urinary Retention, Overactive Bladder

This is a Phase 3 randomized double-blind placebo controlled study Assessing the Efficacy and Safety of Anti-Spike SARS-CoV-2 Monoclonal Antibodies in Preventing SARS-Cov-2 Infection in Household Contacts of Individuals Infected with SARS-CoV-2

Location(s): Jacksonville (Headquarters)

Condition: COVID-19

This is a Phase 2a study being done to evaluate the efficacy, safety, PK, and immunogenicity of multiple doses of MEDI3506 in adult subjects with DKD.

Location(s): Jacksonville- LaVilla (Downtown)

Condition:

This study is being done to assess the efficacy and safety of tirzepatide compared to dulaglutide in patients with type 2 diabetes and increased cardiovascular risk.

Location(s): Jacksonville- LaVilla (Downtown), Macon

Condition: Diabetes, Heart Disease

ECO-RESET: is a Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, Multi-center study to assess the efficacy and safety of SER‑287 in adults with active mild-to-moderate ulcerative colitis

Location(s): St. Augustine

Condition: Ulcerative Colitis

PRECISION: The study is to evaluate the blood pressure lowering effect of aprocitentan when added to other anti-hypertensive drugs of patients with difficult to control (resistant) high blood pressure (hypertension), and to show that blood pressure reduction is kept for long period of time.

Location(s): St. Augustine

Condition: Resistant Hypertension

This randomized, double-blind, placebo controlled, parallel group study being done to provide data on the efficacy, safety, tolerability and pharmacokinetics of multiple dose of PF-06882961 in adults with type 2 diabetes mellitus that are inadequately controlled on metformin and/or diet and exercise.

Location(s): Jacksonville (Headquarters), Jacksonville- LaVilla (Downtown), Macon

Condition: Diabetes

Protocol I8F-MC-GPHR(a) A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study Comparing the Efficacy and Safety of Tirzepatide versus Placebo in Patients with Nonalcoholic Steatohepatitis (NASH)

Location(s): Jacksonville- LaVilla (Downtown)

Condition: Nonalcoholic Steatohepatitis

SELECT – Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity

Location(s): Jacksonville (Headquarters)

Condition: Heart Disease

A Double-blind Randomized Placebo-controlled Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Atherosclerotic Cardiovascular Disease

Location(s): Jacksonville (Headquarters), Jacksonville- LaVilla (Downtown), Lake CIty, Macon, St. Augustine

Condition: Cholesterol, Heart Disease

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes (FOCUS)

Location(s): Jacksonville (Headquarters)

Condition: Diabetes

A Multicentre International Randomized Parallel Group Double-blind Placebo-controlled Clinical Trial of EMPAgliflozin Once Daily to Assess Cardio-renal Outcomes in Patients With Chronic KIDNEY Disease

Location(s): Jacksonville (Headquarters), Jacksonville- LaVilla (Downtown), Lake CIty, Macon

Condition: Kidney Disease